Important new research investigating Long QT Syndrome birth control risks finds progestin-only birth control can increase cardiac risk in women with Long QT Syndrome (LQTS)— especially type 2 — unless paired with β-blockers. The study, co-authored by Dr. Ayhan Yoruk, examines how certain oral contraceptives (birth control pills) affect women living with congenital LQTS, a heart rhythm disorder that can cause dangerous arrhythmias.
Why This Matters
Many women with LQTS face complex decisions about birth control. Until now, little was known about how different types of oral contraceptives (OCs) might influence heart health in these patients. This study, using the Rochester LQTS Registry, provides much-needed guidance for women and their healthcare providers.
The Study in Brief
Researchers followed 1,659 women with LQTS from their first menstrual cycle through age 40. Of these, 370 women (22%) used oral contraceptives. The team categorized pills into three types:
- Progestin-only pills
- Estrogen-only pills
- Combination pills (estrogen + progestin)
They then tracked the number of cardiac events—including fainting (syncope), cardiac arrest, and sudden cardiac death—over more than 35,000 years of combined follow-up.
Key Findings
- Progestin-only pills increased risk: Women using progestin-only birth control had a 2.8-times higher risk of dangerous heart events if they were not taking β-blocker medication.
- β-blockers are protective: When women on progestin-only pills also took β-blockers, their risk was dramatically reduced (about 78% lower).
- LQTS type 2 is higher risk: Women with the LQTS type 2 genetic variant had the highest risk when using progestin-only pills without β-blockers.
Understanding Long QT Syndrome Birth Control Risks
If you have LQTS, especially type 2, talk with your cardiologist before starting any form of birth control. Progestin-only pills should generally be avoided unless you are also on prescribed β-blocker therapy. Combination or estrogen-only options may be safer for some women, but every case is different.
Takeaway Message from Dr. Ayhan Yoruk, of The Heart Rhythm Clinic:
“Our research underscores the importance of personalized medicine. Birth control is not one-size-fits-all — especially for women with inherited heart rhythm disorders. With the right precautions and medical supervision, we can keep patients safe while respecting their reproductive health needs.”
The Heart Rhythm Clinic
If you have LQTS and are considering birth control, schedule an appointment with Dr. Ayhan Yoruk at The Heart Rhythm Clinic. We can help you choose a safe option that works with your lifestyle and medical history.
